Automation of Automated NGS Library Preparation Boosting Workflow

The usage of next-generation sequencing (NGS) has recently expanded dramatically, and it has subsequently become a valuable tool in the diagnosis of numerous diseases.

Next-generation sequencing is used for research and clinical diagnostic applications. NGS is a genome sequencing technology that determines the order of nucleotides in targeted regions of deoxyribonucleic acid (DNA) or ribonucleic acid (RNA), or entire genomes.

The clinical applications of NGS include disease diagnosis, prognosis, therapeutic decision, and follow-up of patients.

Converting native DNA into a barcoded library is a highly technical procedure that takes a lot of time and materials. Furthermore, the prepared library is prone to errors, and a single glitch might contaminate entire testing findings.

This can be solved with the use of specialist automation solutions, such as liquid handling equipment or integrated microfluidic systems. These automated next-generation sequencing (NGS) library preparation methods can save time and money while also reducing testing errors.

What are the advantages of automated NGS library preparation?

Library preparation automation is the bottleneck step in the entire next-generation sequencing workflow. This is because of the otherwise decreasing cost of next-generation sequencing. With the help of volume miniaturization of automated liquid handlers, the cost and throughput challenges can be overcome, which might enable researchers to process more samples while also generating more data.

There are several advantages to transitioning from manual to automated NGS library preparation. Automated NGS library preparations are more efficient, speedy, and less prone to human error. They are also less prone to contamination, making them more constant and dependable. Furthermore, adopting these automated devices can improve the quality of workflow and aid in workflow optimization.

The vast potential for automated NGS library preparation adoption in emerging economies, as well as technological improvements in automated NGS library preparation, are likely to generate growth possibilities for market participants.

According to a report published by BIS Research, the global NGS library preparation automation market was valued at $1.27 billion in 2022, and it is expected to reach $3.80 billion by 2029, growing at a CAGR of 14.85% during the forecast period 2022–2029.

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With the increasing demand for next-generation sequencing, the global NGS library preparation automation market is expected to grow as there is no human error when the system is fully automated. Additionally, it saves time and money.

How is automated NGS library preparation the key to optimizing workflow?

With limited human involvement, this workflow has minimal potential for error and user variability as compared to conventional systems. As a result, sample quality gets improved, and the ability to produce high-quality libraries consistently increases.

Fully automated NGS library preparation solutions provide a higher library preparation quality and transform the efficiency of the workflow.

NGS library preparation automation is beneficial as it helps increase the lab’s efficiency and generates more consistent results. Automation helps in expanding sample workload and maintaining turnaround time.

Next-generation sequencing (NGS) is a strong and widely available high-throughput technology for learning about any species at the genomic, transcriptome, or epigenetic level.

Advancements in Automated NGS Library Preparation

NGS library preparation used to be complex and labor intensive, but in recent years, major advances have been made in automating the process, making it less error prone. However, it is still critical to ensure that the automated process is well specified because what goes into the library preparation instrument is what comes out.

As a result, even minor setup errors can degrade data quality. Many biotechnology and pharmaceutical companies have begun to sell kits for NGS library repair to streamline the entire procedure. These are known as automation-ready kits.

Acknowledging the future potential for massive growth in the demand for applications for NGS library preparation automation, biotechnology and life science companies, such as Hamilton Company, Tecan Trading AG, and Danaher, have invested substantially to aid further developments in the NGS library preparation automation market.


With the emergence of NGS technology, a significant decrease in DNA sequencing costs has been observed, making the technology accessible to scientists worldwide. This technology involves sample pre-processing, library preparation, sequencing, and bioinformatics.

The global NGS library preparation automation market is well-established and is expected to grow further in the coming years due to the continuous increase in the demand for NGS, as, with an automated system, human errors are not expected.

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BIS Research offers exclusive market intelligence reports on disruptive technologies. Each year we publish over 200 titles across industry verticals.